I doubt any car could run on two cylinders, with satisfactory results. I do know that for a number of years now, some models offer a shut down a couple of cylinders during cruising speeds. When acceleration is needed, it will revert back to full cylinders. All a measure of saving fuel. Usually seen from 8 cylinders to 6. Not sure of current possibilities in even newer technology. Many models in today's line up have great performance with 4 cylinders.
This reply is extremely helpful and informative to me Jett. Clearly I don't have a clue and the info you provided is useful and I appreciate it! Thank you m'dear and Happy Monday to you! :)
Volkswagen and Volvo both produce a V5, and Daihatsu built the Charade which had a very effective 1-litre inline 3. Honda tried a 2-cylinder engine in the City 3-door hatch but it didn't work too well, being essentially a modified motorcycle power plant. Didn't produce the torque required to push a heavier vehicle.
Benedict Arnold 