Any cancer can metastasize and that is not good. Better that it is localized and excised. Once it spreads to other organs and takes over the body...well...let us just say that is not good. So we have a stage 4 metastasized john of don "leader". Is he fatal? Are our days numbered and doom certain? Is the end near? Do you hear the dirge off stage getting louder? What do you hear m'dear?