I expect anything you do might have some potential danger attached to it. Would you ever undergo "rewiring" your brain for something severe?

I once lived for two and a half years with a man who was bi-polar. Manic-depressive they called it back then. He was prone to the most severe form.
When I first met him, he has already experienced shock therapy three-times. He had developed an absolute horror of it.
It caused temporary amnesia. At first, afterwards, he didn't know who he was - everything was gone except English language. It took up to two years for his memories to return, and as they did, so did his personality, education, capacity to earn a living and so forth.
It did work in the sense of taking him out of catatonic depression - but the loss of memory was itself depressing and required drugs to help him attain a minimal degree of self-sufficient functioning.
I think shock therapy is cruel.
The future might offer better alternatives through gene therapies - since bipolar disorder is caused by three specific recessive genes.
In the meantime, regular monitoring of the Lithium level in the blood - backed up by a continually adjusted Lithium supplement - is the most effective treatment.