Active Now

Nanoose
WelbyQuentin
my2cents
BB
Thebigd
SpunkySenior
Discussion » Questions » Current Events and News » American Journal of Medicine says use of HCQ effective for Covid-19. How many could been saved if medicine was not politicized?

American Journal of Medicine says use of HCQ effective for Covid-19. How many could been saved if medicine was not politicized?

https://www.amjmed.com/article/S0002-9343(20)30673-2/fulltext#seccesectitle0016


Posted - January 28

Responses


  • 12876
    HCQ is NOT mentioned in the flow chart, and testing was suspended in Australia, the UK, Italy and the US when it resulted in several near-fatal infarctions. It's. Not. Safe.
    It's an antimalarial drug and can only be used in strictly limited conditions due to the strain it puts on the cardiovascular system in general and the heart in particular.
      January 28, 2021 3:13 PM MST
    2

  • 27238
    May want to look again. 

    4th line down. HCQ 200 mg ...
      January 28, 2021 3:19 PM MST
    0

  • 12876
    Causing a micro or overt thrombosis. It's. Not. Safe.
      January 28, 2021 3:25 PM MST
    1

  • 27238
    AMJ says use it. 
      January 28, 2021 3:33 PM MST
    0

  • 12876
    One article, that doesn't show any peer reviews.
      January 28, 2021 3:41 PM MST
    0

  • 27238
    IT IS A REVIEW written by 21 doctors.  The original paper/article was written in Aug 2020.
      January 28, 2021 6:18 PM MST
    0

  • 18356
    From your "review" article:
    "On May 14, 2020, after about 1 million cases and 90,000 deaths in the United States had already occurred, the National Institutes of Health (NIH) announced it was launching an outpatient trial of hydroxychloroquine (HCQ) and azithromycin in the treatment of COVID-19.  A month later, the agency announced it was closing the trial because of the lack of enrollment with only 20 of 2000 patients recruited.  No safety concerns were associated with the trial. This effort serves as the best current working example of the lack of feasibility of outpatient trials for COVID-19. It is also a strong signal that future ambulatory trial results are not imminent or likely to report soon enough to have a significant public health impact on clinical outcomes."
      January 28, 2021 9:29 PM MST
    1

  • 27238
    It is a review. No need for quotes.

    Correct trials were not able to be performed. Because the medicine (that is even available OTC in some countries) was politicized and they had to cancel.    NOT because of safety issues but lack of enrollment.  Media scared public so much they could not get people to take it.  Shame on our media. 

    The article is based observed evidence in cases.  Not trials..(could not get people to do the trials). That is what you quoted above. 
    Also from the review:
    If clinical trials are not feasible or will not deliver timely guidance to clinicians or patients, then other scientific information bearing on medication efficacy and safety needs to be examined 

    And after evalutating information from the begining of the virus.  These Doctors believe HCQ with the Azithromycin or other MYLARIA drugs if HCQ not appropriate. 

      January 29, 2021 6:15 AM MST
    0

  • 18356
    And after evalutating information from the begining of the virus.  These Doctors believe HCQ with the Azithromycin or other MYLARIA drugs if HCQ not appropriate.
      January 29, 2021 9:02 AM MST
    0

  • 27238
    if HCQ not appropriate.

    We all have personal medical reactions to different drugs.  Just as most of us can take Penicillin and a minority of people cannot.  This does not mean Penicillin is a danger to the general public. 

    First choice of the Doctors is HCQ because of its long time use with limited side effects.   (It is also cheap)
      January 29, 2021 9:32 AM MST
    0

  • 18356
    If HCQ is so effective, why is Oklahoma looking to return $2 million dollars of it?  Why, because those idiots listened to Trump and stockpiled it thinking they were smart.  HCQ is NOT the preferred treatment for Covid-19.
      January 29, 2021 9:49 AM MST
    1

  • 27238
    Oklahoma bought too much.  They bought over 1M doses and have only had 21,000 cases total that even needed hospitalization. Under 400K cases total.  

    https://oklahoma.gov/covid19.html

    HCQ with Azithromycin is the first choice in the original article and in the review by the 21 Doctors. 
      January 29, 2021 12:50 PM MST
    0

  • 18356
    Well, if you want to go back to original protocols, we should start blood-letting again because it worked so well for the Middle Ages.
      January 29, 2021 2:28 PM MST
    0

  • 27238
    Yeah because 2020 was soooo long ago.   
      January 29, 2021 3:06 PM MST
    0

  • 18356
    No, because HGQ was the protocol Trump was telling everyone they should be using to treat Covid-19.  And, just as Dr. Fauci who was wrong originally about wearing masks, and changed his advice when the science showed he was wrong, Trump never admitted that NCQ was ineffective.  It's OK for you to harp on Dr. Fauci making an incorrect decision, but it's OK for you to continue to put forth non-factual information that HCQ is what you think doctors are recommending.  
      January 29, 2021 10:42 PM MST
    1

  • 18356
    "On May 14, 2020, after about 1 million cases and 90,000 deaths in the United States had already occurred, the National Institutes of Health (NIH) announced it was launching an outpatient trial of hydroxychloroquine (HCQ) and azithromycin in the treatment of COVID-19.  A month later, the agency announced it was closing the trial because of the lack of enrollment with only 20 of 2000 patients recruited.
      January 28, 2021 3:57 PM MST
    0

  • 27238
    And now in Jan 2021 they are recommending it as outpatient normal treatment.

    Hydroxychloroquine (HCQ) is an antimalarial/anti-inflammatory drug that impairs endosomal transfer of virions within human cells. HCQ is also a zinc ionophore that conveys zinc intracellularly to block the SARS-CoV-2 RNA-dependent RNA polymerase, which is the core enzyme of the virus replication.  The currently completed retrospective studies and randomized trials have generally shown these findings: 1) when started late in the hospital course and for short durations of time, antimalarials appear to be ineffective, 2) when started earlier in the hospital course, for progressively longer durations and in outpatients, antimalarials may reduce the progression of disease, prevent hospitalization, and are associated with reduced mortality.        In a retrospective inpatient study of 2541 patients hospitalized with COVID-19, therapy associated with an adjusted reduction in mortality was HCQ alone (hazard ratio [HR] = 0.34, 95% confidence interval [CI] 0.25-0.46, P <0.001) and HCQ with azithromycin (HR = 0.29, 95% CI 0.22-0.40, P <0.001).  HCQ was approved by the US Food and Drug Administration in 1955, has been used by hundreds of millions of people worldwide since then, is sold over the counter in many countries, and has a well-characterized safety profile that should not raise undue alarm. ,  Although asymptomatic QT prolongation is a well-recognized and infrequent (<1%) complication of HCQ, it is possible that in the setting of acute illness symptomatic arrhythmias could develop. Data safety and monitoring boards have not declared safety concerns in any clinical trial published to date. Rare patients with a personal or family history of prolonged QT syndrome and those on additional QT prolonging, contraindicated drugs (eg, dofetilide, sotalol) should be treated with caution and a plan to monitor the QTc in the ambulatory setting. A typical HCQ regimen is 200 mg bid for 5 days and extended to 30 days for continued symptoms. A minimal sufficient dose of HCQ should be used, because in excessive doses the drug can interfere with early immune response to the virus.
      January 28, 2021 6:04 PM MST
    0

  • 7174
    Probably a fraction of those who could have been saved if wearing masks had not been politicized.
      January 29, 2021 3:53 AM MST
    3

  • 27238
    Masks would not have been politized if Dr Fauci, Birx, Surgent General etc did not spend 2 months telling Americans that masks were NOT needed and that they would in fact spread the virus by normal people not wearing them properly.  ie. ill person wears mask. Ill person adjusts mask. Germ is on their hands. Germs are now being transfered to everything the ill person touches. This would apply to mask that gets the germs on the outside of the mask. 
    Fauci has even admitted masks a symbolic.
    But they may stop a droplet. 

    If masks work so well...NY and CA should have been open along time ago. 
      January 29, 2021 5:48 AM MST
    0

  • 6518
    Doctors generally don't want people to die and I am sure they will treat patients with whatever seems most effective. I'd worry that the HCQ, for whatever reason hasn't been properly evaluated and proven. That people are not using it suggests to me that doctors have grave doubts about the efficacy - a trial would have solved that for sure but I think that there was no enthusiasm for a trial says something quite telling
      January 29, 2021 1:03 PM MST
    1

  • 27238
    Your are right it has not been evaluated with proper trials for SARS-2.   Because the media scared people and they could not get participants to do the trials. 

    The review I linked shows that HCQ with Zinc helps if used early.  They came to this decision after evaluating different countries and doctors word wide results.   The review is new from  Jan 2021.

    Personally, I know what Doctor to go to in my area if I or someone I know gets the virus. 

      January 29, 2021 3:17 PM MST
    0