Humorous answers only, please: what’s something that you should never poke with a sharpened stick? ~

A trump supporter.
A woman.

Trump
     He is so full of it
that the hole from the poke
would release all of that
toxicity in him...

However gently you inserted the sharp end of your stick, she'd fart worse than a decaying skunk, plus there'd be all that nasty stuff coming out of her so you'd better stand back when you pperform the insertion. And she'd probably expel at least fifteen of her twenty or so brain cells along with it. But she didn't make sense before so it probably won't make much difference, ha, ha.
Oh wait, my boyfriend's sister tells me Pelosi's not dead yet. OK, so the nasty stuff comes later.
Don't know how you'd do it though. I heard she has a sturdy castle wall to keep out the riff raff. Let me know.

A woman, especially one who is angry. 

That grammer cops asleep!  Shhh, don't wake him up by pokeing him with that sharp stick!

A quick brown fox.  Because if you do, then he’ll jump over a lazy dog.  This will start the dog laughing.  He’ll laugh so hard that he’ll knock over a fiddle onto a cat.  The cat will be so terrified it’ll jump on the back of the cow.  The pain of the cat’s claws digging into the cow will be so severe that the cow will jump over the moon.  Once that happens, all heck will break loose.  Why, the next thing you know dinnerware will start eloping with cutlery and we’ll have a regular “pan”-demic on our hands.  

A British Army PT instructor. They prefer to be attacked with fruit.