A little yes but I try to separate whether I am being personally targeted or just generically targeted. And I take whatever the criticism is seriously and think about it before I respond. I realize not everyone with agree with me and sometimes those who do not agree will feel they have to strike out at someone because they somehow feel personally threatened. All of which I try to take into account.
I would think anyone who attacks me would be more than happy to do so openly - people here aren't generally backwards in coming forwards with the insults. They are often a little veiled but not very. So generally that makes it easy to respond.
I don't think it happens that often that people insult me indirectly - perhaps I just don't notice, but I would need to be very sure that they were trying to insult me not just something I believe in. Like I am a feminist, I think everyone should be, not the militant kind but the kind which believes in respect and fairness for all - I don't particularly enjoy anti-feminist posts and I do often respond to those but I have never ever felt that people were directly or even indirectly insulting me when they criticise feminists..
Your not an emotionally disturbed old lady are you? Then dont sweat it big guy. Its not you. Well, its you, but not in this instance, its always you....-shiver- ;D
Yes, it does make me uncomfortable. It can seem like the purpose of those questions is to state something in a way that makes the poster seem like an innocent victim and to garner support for herself/himself. To me, it can look like the poster is a big crybaby who cannot thoughtfully reflect on why someone else's opinion has any merit.
~ 
Randy D 